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The exact mechanisms through which activation of THR improves MASH are still unclear but are known to control fat synthesis, regulate fatty acid oxidation, regulate cholesterol metabolism, improve mitochondrial function, and reduce inflammation and fibrosis

For now, this early evidence points to potential short-term benefit, but the long-term story remains untold

Others, including the FDA and Eli Lilly, have argued that adding commonly available vitamins to avoid the "essentially a copy" restriction does not constitute a legitimate clinical modification

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